Hypothalamic Dysfunction in “Cured” Acromegaly Is Treatment Modality Dependent
نویسندگان
چکیده
منابع مشابه
[Hypothalamic dysfunction in obesity].
Obesity, defined as abnormal or excessive fat accumulation that may impair life quality, is one of the major public health problems worldwide. It results from an imbalance between food intake and energy expenditure. The control of energy balance in animals and humans is performed by the central nervous system (CNS) by means of neuroendocrine connections, in which circulating peripheral hormones...
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Acromegaly is associated with a two-threefold increase in cardiovascular mortality compared to the normal population (1). Before the introduction of modern, effective therapeutic modalities, about 80% of these patients died before the age of 60 from cardiovascular disease (2). It is usually explained by the high prevalence of risk factors leading to atherosclerosis, such as hypertension, type 2...
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One hundred seventy-two acromegalics who were operated on using the trans-sphenoidal approach underwent long-term follow-up evaluation. Sixty-four received 100 tLg octreotide subcutaneously three times daily: for 3 to 6 weeks before surgery in 14 patients (group 1); and for 3 to 9 months in 41 and for 13 to 39 months in nine (n = 50, group 2), In 18 group 2 patients, the dose was increased step...
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Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting pituitary adenoma and leads to acromegaly - a disorder of disproportionate skeletal, tissue, and organ growth. High GH and IGF1 levels lead to comorbidities including arthritis, facial changes, prognathism, and glucose intolerance. If the condition is untreated, enhanced mortality due to cardiovascular, cerebrov...
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“Aging is not a beautiful thing.“ This sentence is heard by many patients of acromegaly at their visit to the doctor. The changes in the body are often not recognized or misclassified by medical professionals for a very long time. Often, a diagnosis is only reached after 9 or even 10 years. A visit to the endocrinologist can shed light on the condition, however. There is an excess production of...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1998
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.83.5.4832